A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
Quotes about mutations (16 Quotes)
The obvious issue that we and others, no doubt including the present authors, will wish to establish is what are the selective advantages of the mutations that are seen,
First of all, many human diseases are influenced by, if not caused by mutations in genes.
The complete sequence of the 1918 virus, demonstrating its avian origin, and focusing on those mutations that differentiate avian from human strains will be immensely helpful as we try to understand the factors that govern the epidemic behavior of the current crop of avian H5 viruses.
We now see that natural selection is working to conserve this unpartnered region of the Y, ... If mutations do occur in any of these genes, they don't seem to pass on in the lineage. This is a clear example of how evolution is not just about moving ahead, it's also about not falling behind.
Importantly, such insights can now guide studies that focus on the normal function and interactions of these proteins and how they might be enhanced by disease-causing mutations. These studies could give better understanding of how the proteins cause dise
Freedom comes only to those who no longer ask of life that it shall yield them any of those personal goods that are subject to the mutations of time.
Language thus becomes monumental because of the mutations of advertising.
Even though mutations per se may arise in fewer numbers in humans than in chimpanzees, those that matter will quickly spread. Mutations that are advantageous to the human, such as intelligence, probably are under strong natural selection.
Nine years is a long time. Half the scientific community feels it might never happen. What we suggested in the paper is a kind of potential foothold situation where if it can actually get into the human population, it can undergo further mutations to optimize itself.
The function of literature, through all its mutations, has been to make us aware of the particularity of selves, and the high authority of the self in its quarrel with its society and its culture. Literature is in that sense subversive.
Having identified these previously unknown mutations in key cancer causing genes, we will hopefully enable the development of small molecules and antibodies to regulate their abnormal function and thus inhibit the growth of cancerous cells. This collaborative study exemplifies exactly what our coalition was formed to do -- leverage our individual institution's expertise to collectively discover new druggable targets through genome sequencing and functional genomic analysis.
This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.
We've known for some time that smokers are under oxidative stress, because the smoke itself is an oxidant that creates free radicals and cell mutations. The immune response of the body also tends to cause inflammation, and this inflammation is one reason that smoking relates not only to lung cancer but other serious health problems such as diabetes, hypertension and heart disease.
I suspect any worries about genetic engineering may be unnecessary. Genetic mutations have always happened naturally, anyway.
Patients (in the study) went through an induction and maintenance phase (consisting of fewer drugs), while patients now continue on a chronic three-drug therapy. If somebody is failing chronic administration of three drugs, it could be that they have mutations from all of the components.