The region of DNA identified in our study showed evidence of replication in four independent series of experiments. I haven't seen a putative risk factor show such consistent results since the e4 variant of the APOE gene was identified as a risk factor for late-onset Alzheimer's disease more than 10 years ago.
Quotes about apoe (3 Quotes)
It seems that physical activity had an even more pronounced effect among those with the susceptibility gene apoe4, the most important risk factor for Alzheimer's disease and dementia.
There are a few genes that have been implicated in the development of early-onset Alzheimer's disease, but other than APOE, no genes have been found that increase risk for the more common, late-onset form of the disease.