The region of DNA identified in our study showed evidence of replication in four independent series of experiments. I haven't seen a putative risk factor show such consistent results since the e4 variant of the APOE gene was identified as a risk factor for late-onset Alzheimer's disease more than 10 years ago.
More Quotes from Alison Goate:
Most people have a receptor that's very sensitive to the bitter-tasting compound, but in people that have this variant form, they can tolerate higher concentrations of this bitter compound without it tasting nasty to them.Alison Goate
We don't know which of those genes is most likely to harbor this particular risk factor for Alzheimer's disease, but we're getting closer. We're now trying to nail down which one of these six genes is the most likely to be involved.
Alison Goate
There are a few genes that have been implicated in the development of early-onset Alzheimer's disease, but other than APOE, no genes have been found that increase risk for the more common, late-onset form of the disease.
Alison Goate
In earlier work, we had identified chromosome 7 as a region where there was likely to be a gene-influencing alcoholism risk.
Alison Goate
When we understand more about the genes and the environmental factors that influence someone's risk, I think you will be better able to predict who is at highest risk and then target your prevention strategies at those high-risk individuals.
Alison Goate
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Based on Topics: Danger & Risk QuotesBased on Keywords: apoe, late-onset, putative, replication, variant
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