Without BDNF in the circuit, an animal can't learn that a social stimulus is threatening and respond appropriately.
More Quotes from Eric Nestler:
One of the cardinal features of addiction is how long-lived it is, ... A key question in the field has been By what mechanisms do drugs of abuse cause changes in the brain that last this long.Eric Nestler
The molecular scar induced by chronic stress in the hippocampus, and perhaps elsewhere in the brain, can't be easily reversed. To really cure depression, we probably need to find new treatments that can remove the silencer molecules.
Eric Nestler
That would make addiction more inheritable than diseases we commonly think of as genetic, such as adult onset diabetes or common hypertension,
Eric Nestler
Our study provides insight into how chronic stress triggers changes in the brain that are much more long-lived than the effects of existing antidepressants.
Eric Nestler
The social-defeat process induced production of BDNF in the reward circuit. Without BDNF in the circuit, an animal can't learn that a social stimulus is threatening and respond accordingly.
Eric Nestler
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Based on Topics: Animals QuotesBased on Keywords: bdnf
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