There was an enormous literature of stereochemical fact which had not been interpreted properly in its three-dimensional aspects.
There was an enormous literature of stereochemical fact which had not been interpreted properly in its three-dimensional aspects.
It does not seem, however, that organic chemists were much worried about barriers to rotation in organic molecules in general at that time because there was no technique available to demonstrate the phenomenon experimentally.
The first serious applications were in triterpenoid chemistry.
X-Ray crystallography is nowadays an accurate and rapid method of determining conformation in the crystal lattice, which conformation usually corresponds to the preferred conformation in solution.
Many transition states have a well-defined preferred geometrical requirement.
Every chemical reaction has a transition state.
In general the preferred conformation in the crystalline state is that which would be predicted by the principles of conformational analysis.
© 2020 Inspirational Stories
© 2020 Inspirational Stories